CJC-1295 With And Without DAC 2: Complete Guide
CJC-1295 With And Without DAC 2: Complete Guide
CJC-1295 With and Without DAC 2: Complete Guide
What is CJC-1295
CJC-1295 is a synthetic peptide that mimics the natural growth hormone-releasing hormone (GHRH) produced by the hypothalamus. By binding to GHRH receptors in the pituitary gland, it stimulates the secretion of growth hormone (GH). The peptide is often used by athletes, bodybuilders, and those interested in anti-aging therapies because elevated GH levels can promote muscle growth, fat loss, improved recovery, and overall vitality.
The Study & Development
The development of CJC-1295 began in the early 2000s as part of a broader effort to create long-acting GHRH analogues for clinical use. Early animal studies demonstrated that CJC-1295 could increase GH secretion over several days with a single injection, unlike traditional GHRH peptides that required frequent dosing. Subsequent human trials focused on safety and pharmacokinetics, revealing a favorable profile with minimal side effects at therapeutic doses. The peptide’s long half-life—especially when paired with a drug affinity complex (DAC)—has made it attractive for both medical and performance applications.
What’s the difference? With V.S. Without!
CJC-1295 exists in two primary forms: the basic version and the version coupled to a DAC. The DAC is a small molecule that binds to the peptide, extending its circulation time by preventing rapid renal clearance and proteolytic degradation.
Without DAC: Rapid absorption but also faster elimination. Peak GH levels are reached quickly, but the effect wanes within 24–48 hours. Users often need daily or twice-daily injections to maintain stable hormone levels.
With DAC (CJC-1295 DAC): The peptide remains in the bloodstream for up to 14 days after a single injection.
CJC-1295 With And Without DAC 2: Complete Guide
CJC-1295 With and Without DAC 2: Complete Guide
What is CJC-1295
CJC-1295 is a synthetic peptide that mimics the natural growth hormone-releasing hormone (GHRH) produced by the hypothalamus. By binding to GHRH receptors in the pituitary gland, it stimulates the secretion of growth hormone (GH). The peptide is often used by athletes, bodybuilders, and those interested in anti-aging therapies because elevated GH levels can promote muscle growth, fat loss, improved recovery, and overall vitality.
The Study & Development
The development of CJC-1295 began in the early 2000s as part of a broader effort to create long-acting GHRH analogues for clinical use. Early animal studies demonstrated that CJC-1295 could increase GH secretion over several days with a single injection, unlike traditional GHRH peptides that required frequent dosing. Subsequent human trials focused on safety and pharmacokinetics, revealing a favorable profile with minimal side effects at therapeutic doses. The peptide’s long half-life—especially when paired with a drug affinity complex (DAC)—has made it attractive for both medical and performance applications.
What’s the difference? With V.S. Without!
CJC-1295 exists in two primary forms: the basic version and the version coupled to a DAC. The DAC is a small molecule that binds to the peptide, extending its circulation time by preventing rapid renal clearance and proteolytic degradation.
Without DAC: Rapid absorption but also faster elimination. Peak GH levels are reached quickly, but the effect wanes within 24–48 hours. Users often need daily or twice-daily injections to maintain stable hormone levels.
With DAC (CJC-1295 DAC): The peptide remains in the bloodstream for up to 14 days after a single injection.